Difference between revisions of "Support:Documents:Examples:Estimate Change of Neurotransmitter"
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==Overview== | ==Overview== | ||
| − | The changes of endogenous neurotransmitter by PET scanning after a stimulus has been proved with different approaches. In stead of detecting the increase or decrease of neurotransmitter, it is important to characterize the temporal change of a neurotransmitter after a | + | The changes of endogenous neurotransmitter by PET scanning after a stimulus has been proved with different approaches. In stead of detecting the increase or decrease of neurotransmitter, it is important to characterize the temporal change of a neurotransmitter after a stimulus. [http://www.ncbi.nlm.nih.gov/pubmed/16285909?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Morris] proposed the new technique for capturing the dynamic changes of a neurotransmitter after a stimulus and demonstrated the ability of this method to reconstruct the temporal characteistics of an enhance in neurotransmitter concentration. |
Here we present a general model of ntPET, which can be simplified to Morris' model. | Here we present a general model of ntPET, which can be simplified to Morris' model. | ||
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[[Image:Model.jpg]] | [[Image:Model.jpg]] | ||
| − | Generally, there are two separate PET scans: rest condition (without any stimuli) and activation conditon (after a stimulus) | + | Generally, there are two separate PET scans: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus). |
===Implementing the Compartment Model=== | ===Implementing the Compartment Model=== | ||
==Create a new model for ntPET== | ==Create a new model for ntPET== | ||
Revision as of 19:06, 25 February 2009
Model of Neurotransmitter PET (ntPET)
Overview
The changes of endogenous neurotransmitter by PET scanning after a stimulus has been proved with different approaches. In stead of detecting the increase or decrease of neurotransmitter, it is important to characterize the temporal change of a neurotransmitter after a stimulus. Morris proposed the new technique for capturing the dynamic changes of a neurotransmitter after a stimulus and demonstrated the ability of this method to reconstruct the temporal characteistics of an enhance in neurotransmitter concentration.
Here we present a general model of ntPET, which can be simplified to Morris' model.
Generally, there are two separate PET scans: one for the rest condition (without any stimuli) and the other for the activation conditon (after a stimulus).