Difference between revisions of "Support:Documents:Examples:Estimate Change Neurotransmitter"

Revision as of 00:42, 24 February 2009

Underwork

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-== Estimating Input Delay and Rate Constants ==
+== Estimate neurotransmitter of PET (ntPET) imaging==
-This example demonstrates an approach to simultaneously estimating input function delay along with parameters of the 1-tissue compartment (e.g. blood flow) model.
+Underwork
-For the sake of generality, this could be interpreted as a dynamic contrast-enhanced (DCE) MRI or perfusion PET study.
-==== Tissue uptake ====
+==== Background====
-This model has one tissue compartment.  Material in the blood is assumed to rapidly exchange with that in (extravascular) tissue.
-The tissue model has two rate constants: K<sub>1</sub> and k<sub>2</sub> and is depicted in the diagram:
-==== Input function ====
+==== Kinetic model of ntPET ====
-This example also demonstrates how to temporally align measured input function data to the tissue (image) data.  Here the plasma concentration vs. time t is modeled as
-== Example:  Estimating Input Delay and Rate Constants ==