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How people use COMKAT

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Peer-reviewed Articles

Before COMKAT's first public release

1. Muzic RF, Jr., Nelson AD, Saidel GM, Miraldi F. Optimal Experiment Design for PET Quantification of Receptor Concentration. IEEE Trans.Med.Imag. 1996;15:2-12. PubMed

2. Muzic RF, Saidel GM, Zhu N, Nelson AD, Zheng L, Berridge MS. Iterative Optimal Design of PET Experiments for Estimating b-Adrenergic Receptor Concentration. Med.& Biol.Engr.& Comput. 2000;38:593-602. PubMed

The seminal article

3. Muzic RF, Cornelius S. COMKAT: Compartment Model Kinetic Analysis Tool. J.Nucl.Med. 2001;42:636-645. PubMed

Since COMKAT's first public release

4. Yoder KK, Wang C, Morris ED. Change in binding potential as a quantitative index of how to make a crepe neurotransmitter release is highly sensitive to relative timing and kinetics of the tracer and the endogenous ligand. J.Nucl.Med. 2004;45:903-911.

5. Morris ED, Christian BT, Yoder KK, Muzic RF, Jr. Estimation of local receptor density, B'max, and other parameters via multiple-injection positron emission tomography experiments. Methods Enzymol. 2004;385:184-213. PubMed

6. Christian BT, Narayanan T, Shi B, Morris ED, Mantil J, Mukherjee J. Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol. J.Cereb.Blood Flow Metab 2004;24:309-322. PubMed

7. Pain F, Laniece P, Mastrippolito R, Gervais P, Hantraye P, Besret L. Arterial input function measurement without blood sampling using a beta-microprobe in rats. J.Nucl.Med. 2004;45:1577-1582.

8. Morris ED, Yoder KK, Wang C, et al. ntPET: a new application of PET imaging for characterizing the kinetics of endogenous neurotransmitter release. Mol.Imaging 2005;4:473-489. PubMed

9. Bingham EM, Dunn JT, Smith D, et al. Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-D-glucose PET study. Diabetologia 2005;48:2080-2089. PubMed

10. Yoder KK, Kareken DA, Seyoum RA, et al. Dopamine D(2) receptor availability is associated with subjective responses to alcohol. Alcohol Clin.Exp.Res. 2005;29:965-970. PubMed

11. Salinas CA, Muzic RF, Jr., Ernsberger P. PET Imaging of Myocardial B-Adrenergic Receptors with Fluorocarazolol: Lack of Interference by Endogenous Catecholamines. J.Cardiovasc.Pharmacol. 2005;46(2):222-31. PubMed

12. Muzic RF Jr, Christian BT. Evaluation of Objective Functions for Estimation of Kinetic Parameters. Med.Phys. 2006;33(2):342-53. PubMed

13. Christian BT, Lehrer DS, Shi B, et al. Measuring dopamine neuromodulation in the thalamus: using [F-18]fallypride PET to study dopamine release during a spatial attention task. Neuroimage. 2006;31:139-152. PubMed

14. Salinas CA., Muzic RF Jr., Saidel, GM. Validity of model approximations for receptor-ligand kinetics in nuclear medicine, Med Phys. 2007 May;34(5):1693-703. PubMed

15. Constantinescu CC, Bouman C, Morris ED. Nonparametric extraction of transient changes in neurotransmitter concentration from dynamic PET data. IEEE Trans.Med.Imaging 2007;26:359-373. PubMed

16. Morris ED, Yoder KK. Positron emission tomography displacement sensitivity: predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics. J.Cereb.Blood Flow Metab 2007;27:606-617. PubMed

17. Salinas C, Muzic RF, Jr., Ernsberger P, Saidel GM. Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET. Med.Phys. 2007;34:151-165. PubMed

18. Saad A, Smith B, Hamarneh G, et al: Simultaneous segmentation, kinetic parameter estimation, and uncertainty visualization of dynamic PET images; Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):726-33. PubMed

19. Landau BR, Spring-Robinson CL, Muzic RF, Jr., et al. 6-Fluoro-6-deoxy-D-glucose as a tracer of glucose transport. Am.J.Physiol Endocrinol.Metab 2007;293:E237-E245 Pubmed

20. Yoder KK, Constantinescu CC, Kareken DA, et al. Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study, Alcohol Clin Exp Res. 2007 Jun;31(6):965-73. PubMed

21. Normandin MD, Morris ED. Estimating neurotransmitter kinetics with ntPET: a simulation study of temporal precision and effects of biased data. Neuroimage 2008;39:1162-1179. PubMed

22. Fang YH, Muzic RF, Jr. Spillover and Partial-Volume Correction for Image-Derived Input Functions for Small-Animal 18F-FDG PET Studies. J.Nucl.Med. 2008;49:606-614. PubMed

23. Constantinescu CC, Yoder KK, Kareken DA, et al. Estimation from PET data of transient changes in dopamine concentration induced by alcohol: support for a non-parametric signal estimation method. Phys.Med.Biol. 2008;53:1353-1367. PubMed

24. Morris ED, Normandin MD, Schiffer WK. Initial comparison of ntPET with microdialysis measurements of methamphetamine-induced dopamine release in rats: support for estimation of dopamine curves from PET data. Mol.Imaging Biol. 2008;10:67-73. PubMed

25. Wang G, Qi Jinyi. Generalized algorithms for direct reconstruction of parametric images from dynamic PET data. IEEE.Trans.Med.Imag. 2009;28(11):1717-1726. Pubmed

26. Fang YH, Asthana P, Salinas CA, Muzic, RF Jr., Integrated Software Environment Based on COMKAT for Analyzing Tracer Pharmacokinetics with Molecular Imaging, J. Nucl. Med., 2010;51(1):71-84. Pubmed

Manuscripts Under Review

To do... start this list...


1. Muzic RF, Jr., Saidel GM. Adequacy of Compartment Models for PET Receptor Studies, Biomedical Engineering Society Annual Fall Meeting, Oct 4-7, 2001, Durham, NC.

2. Yoder K, Wang C, Morris ED: Potential biases in change in binding potential (Dbp) as a measure of dopamine receptor occupancy. J Nucl Med 2003;44:251P.

3. Morris ED, Wang C, Muzic RF, Jr. A constrained, compound objective function approach for recovery of continuous dopamine fluctuations with PET in small animals. 2003. BrainPET.

4. Morris ED, Wang C., Muzic RF, Jr. PET modeling techniques to replace microdialysis in small animals: can endogenous neurotransmitter changes be measured continuously? 2003. Society of Nuclear Medicine.

5. Morris ED, Yoder KK, Wang C, Normandin MD, Zheng Q, Mock B, Muzic RF, Jr., Froehlich JC. A new method for recovering the temporal response of dopamine to alcohol in the rat striatum via pet and kinetic modeling, Academy of Molecular Imaging, March 2005.

6. Muzic RF, Jr., Comparison of methods for estimating kinetic model parameter values, Academy of Molecular Imaging, March 2005.

7. Salinas CA, Muzic RF, Jr., Saidel GM. Optimal Design for a Robust & Efficient Protocol to Estimate Receptor Concentration using PET with a Heterogeneous Population, Academy of Molecular Imaging, Mar 2006.

8. Spring-Robinson CL, Muzic RF, Jr., Chandramoulli V, Faulhaber PF,. Landau BR. Biodistribution of 6-deoxy-6-[18F]fluoro-D-glucose in Positron Emission Tomography, Academy of Molecular Imaging, Mar 2006.

9. Fang YH, Salinas CA, Asthana P, Muzic RF, Jr., Quantification software for quantitative molecular imaging, Academy of Molecular Imaging, Mar 2006.

10. Muzic RF, Jr., Dowlati A, Waggoner SE, Faulhaber PF, Flick SM, Anderson LW, Apana SM, Berridge MS, Collins JM. [11C]Topotecan PET Imaging Predicts Negative Response of Topotecan Therapy, Academy of Molecular Imaging, Mar 2006.

To do... work on this list...

Conference Proceedings

1. Saad A, Smith B, Hamarneh G, et al: Simultaneous segmentation, kinetic parameter estimation, and uncertainty visualization of dynamic PET images; in Ayache N, Ourselin S, Maeder A, et al (eds): MICCAI Part II, LNCS. Springer Berlin / Heidelberg, 2007, pp 726-733.

2. Normandin MD, Morris ED. Temporal resolution of ntPET using either arterial or reference region-derived plasma input functions. Conf.Proc IEEE Eng Med.Biol.Soc. 2006;1:2005-2008.

To do... work on this list...


1. Phelps ME. PET: Molecular Imaging and Its Biological Applications. Springer, 2004.

2. Morris ED, Endres C, Schmidt K, Christian B, Muzic RF, Jr., Fisher R. Kinetic Modeling in PET, invited book chapter, Emission Tomography, Wernick M, Aarsvold J eds., Harcourt, 2004.


1. Experimental Design for PET Receptor Models, PI: Raymond F. Muzic, Jr., Case Western Reserve University, Whitaker Foundation.

2. In Vivo Quantification of Heart Beta-Adrenergic Receptors, PI, Raymond F. Muzic, Jr., Case Western Reserve University, NIH R01 HL62399.

3. Quantitative FDG-PET for Imaging Woodchuck HCC, PI: Zhenghong Lee, Case Western Reserve University, NIH R01 CA095307.

4. COMKAT: Compartment Model Kinetic Analysis Tool for Quantitative Molecular Imaging, Case Western Reserve University, PI: Raymond Muzic, Jr., NIH R33 CA101073.

5. PET Evaluation of Hemorrhagic Shock and Resuscitation, PI: Vibhudutta Awasthi, University of TX Health Science Center at San Antonio, NIH R21/R33 EB005187.

6. Temporal Response of Dopamine to Alcohol Imaged via PET, PI: Evan D Morris, Indiana University, NIH R21 AA015077-01A2.